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Target
Urokinase-type plasminogen activator
Ligand
BDBM50529255
Substrate
n/a
Meas. Tech.
ChEMBL_1908154 (CHEMBL4410512)
Ki
1208±n/a nM
Citation
 Buckley, BJ; Majed, H; Aboelela, A; Minaei, E; Jiang, L; Fildes, K; Cheung, CY; Johnson, D; Bachovchin, D; Cook, GM; Huang, M; Ranson, M; Kelso, MJ 6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50529255
Synonyms:
CHEMBL4476829
Type:
Small organic molecule
Emp. Form.:
C13H16N8O3
Mol. Mass.:
332.3179
SMILES:
COc1ccc(c(OC)n1)-c1nc(C(=O)NC(N)=N)c(N)nc1N
Structure:
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