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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50453428
Substrate
n/a
Meas. Tech.
ChEMBL_1908481 (CHEMBL4410839)
IC50
<1.000000±n/a nM
Citation
 Palacios, DS; Meredith, EL; Kawanami, T; Adams, CM; Chen, X; Darsigny, V; Palermo, M; Baird, D; George, EL; Guy, C; Hewett, J; Tierney, L; Thigale, S; Wang, L; Weihofen, WA Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT). ACS Med Chem Lett 10:1524-1529 (2019) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50453428
Synonyms:
CHEMBL4205098
Type:
Small organic molecule
Emp. Form.:
C24H19N3O3
Mol. Mass.:
397.426
SMILES:
[H][C@@]1(C[C@]1([H])c1cccnc1)C(=O)Nc1ccc(CN2C(=O)c3ccccc3C2=O)cc1 |r|
Structure:
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