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Target
Chymase
Ligand
BDBM50085359
Substrate
n/a
Meas. Tech.
ChEBML_197655
IC50
2400±n/a nM
Citation
 Hayashi, Y; Iijima, K; Katada, J; Kiso, Y Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. Bioorg Med Chem Lett 10:199-201 (2000) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50085359
Synonyms:
CHEMBL60241 | N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-fluoro-phenyl)-propionamide
Type:
Small organic molecule
Emp. Form.:
C19H19ClFNO2
Mol. Mass.:
347.811
SMILES:
Fc1ccc(CCC(=O)N[C@@H](Cc2ccccc2)C(=O)CCl)cc1
Structure:
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