Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50085420
Substrate
n/a
Meas. Tech.
ChEBML_90573
IC50
>100000±n/a nM
Citation
 Singh, SB; Felock, P; Hazuda, DJ Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity. Bioorg Med Chem Lett 10:235-8 (2000) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50085420
Synonyms:
(4aR,5S)-3,4a-Dimethyl-2-oxo-2,4,4a,5,6,7-hexahydro-naphtho[2,3-b]furan-5-carboxylic acid | CHEMBL306631
Type:
Small organic molecule
Emp. Form.:
C15H16O4
Mol. Mass.:
260.2851
SMILES:
CC1=C2C[C@]3(C)[C@H](CCC=C3C=C2OC1=O)C(O)=O |c:1,9,12|
Structure:
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