Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50085712
Substrate
n/a
Meas. Tech.
ChEMBL_71750 (CHEMBL680272)
Ki
21±n/a nM
Citation
 Rivier, JE; Struthers, RS; Porter, J; Lahrichi, SL; Jiang, G; Cervini, LA; Ibea, M; Kirby, DA; Koerber, SC; Rivier, CL Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:784-96 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50085712
Synonyms:
CHEMBL216534 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Trp, Asp, Glu, D Arg, Leu, (D or L) Doc, Pro, D Ala]GnRH | Cyclo (5-8) [Ac-D Nal, D Cpa, D Trp, Asp, Glu, D Arg, Leu, (L or D) Doc, Pro, D Ala]GnRH
Type:
Small organic molecule
Emp. Form.:
C60H83ClN14O15
Mol. Mass.:
1275.839
SMILES:
CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)C(C)(C)OC(C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C)C(N)=O)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O
Structure:
Search PDB for entries with ligand similarity: