Reaction Details Report a problem with these data
Target
P2X purinoceptor 4
Ligand
BDBM50399183
Substrate
n/a
Meas. Tech.
ChEMBL_1913377 (CHEMBL4415960)
IC50
3300±n/a nM
Citation
 Bibic, L; Herzig, V; King, GF; Stokes, L Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms. J Nat Prod 82:2559-2567 (2019) [PubMed]  Article 
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM50399183
Synonyms:
CHEMBL2180160
Type:
Small organic molecule
Emp. Form.:
C19H15NO3S
Mol. Mass.:
337.392
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1c2ccccc2Oc2ccccc12
Structure:
Search PDB for entries with ligand similarity: