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Target
P2X purinoceptor 3
Ligand
BDBM50532071
Substrate
n/a
Meas. Tech.
ChEMBL_1921835 (CHEMBL4424680)
IC50
52±n/a nM
Citation
 Tobinaga, H; Kameyama, T; Asahi, K; Horiguchi, T; Oohara, M; Tada, Y; Fuchino, K; Jikihara, S; Endoh, T; Kurihara, N; Kanda, Y; Ogawa, M; Tamura, N; Yagi, S; Taniguchi, E; Takahara, Y; Shimada, S; Takeyama, C; Yamamoto, S; Shinohara, S; Kai, H Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds. Bioorg Med Chem Lett 29:688-693 (2019) [PubMed]  Article 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM50532071
Synonyms:
CHEMBL4585133
Type:
Small organic molecule
Emp. Form.:
C27H26N2O5
Mol. Mass.:
458.5057
SMILES:
OCc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1 |c:11|
Structure:
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