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Target
Collagenase 3
Ligand
BDBM50089187
Substrate
n/a
Meas. Tech.
ChEMBL_106624 (CHEMBL717008)
IC50
182±n/a nM
Citation
 Robinson, RP; Laird, ER; Blake, JF; Bordner, J; Donahue, KM; Lopresti-Morrow, LL; Mitchell, PG; Reese, MR; Reeves, LM; Stam, EJ; Yocum, SA Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold. J Med Chem 43:2293-6 (2000) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50089187
Synonyms:
(2R,4S)-4-(4'-fluoro-1,1'-biphenyl-4-yl)-N-hydroxy-5-oxopyrrolidine-2-carboxamide | 4-(4'-Fluoro-biphenyl-4-yl)-5-oxo-pyrrolidine-2-carboxylic acid hydroxyamide | CHEMBL20160
Type:
Small organic molecule
Emp. Form.:
C17H15FN2O3
Mol. Mass.:
314.311
SMILES:
ONC(=O)[C@H]1C[C@H](C(=O)N1)c1ccc(cc1)-c1ccc(F)cc1
Structure:
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