Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM50167073
Substrate
n/a
Meas. Tech.
ChEMBL_1926584 (CHEMBL4429656)
Ki
1400±n/a nM
Citation
 Turku, A; Borrel, A; Leino, TO; Karhu, L; Kukkonen, JP; Xhaard, H Pharmacophore Model To Discover OX1 and OX2 Orexin Receptor Ligands. J Med Chem 59:8263-75 (2016) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50167073
Synonyms:
CHEMBL3798017
Type:
Small organic molecule
Emp. Form.:
C24H26N2O4
Mol. Mass.:
406.4742
SMILES:
COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]c3ccccc3c12 |r|
Structure:
Search PDB for entries with ligand similarity: