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Target
Mu-type opioid receptor
Ligand
BDBM50534063
Substrate
n/a
Meas. Tech.
ChEMBL_1927696 (CHEMBL4430768)
Ki
0.500000±n/a nM
Citation
 Ronsisvalle, S; Aricò, G; Panarello, F; Spadaro, A; Pasquinucci, L; Pappalardo, MS; Parenti, C; Ronsisvalle, N An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain. Bioorg Med Chem 24:5280-5290 (2016) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50534063
Synonyms:
CHEMBL4575464
Type:
Small organic molecule
Emp. Form.:
C31H36N2O2
Mol. Mass.:
468.6297
SMILES:
[H][C@]12Cc3ccc(O)cc3[C@](C)(CCN1CCC(=O)NCC(c1ccccc1)c1ccccc1)[C@H]2C |r,THB:35:34:13.12.14:3.9.2|
Structure:
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