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Target
Heme oxygenase 1
Ligand
BDBM50535263
Substrate
n/a
Meas. Tech.
ChEMBL_1930147 (CHEMBL4433398)
IC50
250±n/a nM
Citation
 Salerno, L; Floresta, G; Ciaffaglione, V; Gentile, D; Margani, F; Turnaturi, R; Rescifina, A; Pittalą, V Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. Eur J Med Chem 167:439-453 (2019) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1 | HMOX1_HUMAN | HO | HO-1 | HO1
Type:
PROTEIN
Mol. Mass.:
32822.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_368941
Residue:
288
Sequence:
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
  
Inhibitor
Name:
BDBM50535263
Synonyms:
CHEMBL4456149
Type:
Small organic molecule
Emp. Form.:
C13H15BrN2
Mol. Mass.:
279.176
SMILES:
Brc1ccc(CCCCn2ccnc2)cc1
Structure:
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