Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50535412
Substrate
n/a
Meas. Tech.
ChEMBL_1930461 (CHEMBL4433712)
IC50
>30000±n/a nM
Citation
 Dal Ben, D; Buccioni, M; Lambertucci, C; Marucci, G; Spinaci, A; Marchenkova, A; Abdelrahman, A; Nistri, A; Müller, CE; Volpini, R Investigation on 2',3'- ACS Med Chem Lett 10:493-498 (2019) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50535412
Synonyms:
CHEMBL4570607
Type:
Small organic molecule
Emp. Form.:
C23H21N5O11
Mol. Mass.:
543.4397
SMILES:
[H][C@]12OC(C)(C)O[C@@]1([H])[C@@H](O[C@@H]2COC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(O)=O)n1cnc2c(N)ncnc12 |r|
Structure:
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