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Target
Cyclin-Y
Ligand
BDBM50535525
Substrate
n/a
Meas. Tech.
ChEMBL_1930925 (CHEMBL4434176)
IC50
45±n/a nM
Citation
 Ferguson, FM; Doctor, ZM; Ficarro, SB; Marto, JA; Kim, ND; Sim, T; Gray, NS Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14. Bioorg Med Chem Lett 29:1985-1993 (2019) [PubMed]  Article 
Target
Name:
Cyclin-Y
Synonyms:
C10orf9 | CBCP1 | CCNY | CCNY_HUMAN | CFP1 | Cyc-Y | Cyclin box protein 1 | Cyclin fold protein 1 | Cyclin-Y | cyclin-X
Type:
PROTEIN
Mol. Mass.:
39339.72
Organism:
Homo sapiens
Description:
ChEMBL_118346
Residue:
341
Sequence:
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
  
Inhibitor
Name:
BDBM50535525
Synonyms:
CHEMBL4576258
Type:
Small organic molecule
Emp. Form.:
C31H34Cl2F3N7O5
Mol. Mass.:
712.547
SMILES:
OC(=O)C(F)(F)F.CN(C)CC\C=C\C(=O)Nc1ccc(cc1)N1CCC(CC1)NC(=O)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl
Structure:
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