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Target
Cyclin-Y
Ligand
BDBM50535536
Substrate
n/a
Meas. Tech.
ChEMBL_1930925 (CHEMBL4434176)
IC50
48±n/a nM
Citation
 Ferguson, FM; Doctor, ZM; Ficarro, SB; Marto, JA; Kim, ND; Sim, T; Gray, NS Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14. Bioorg Med Chem Lett 29:1985-1993 (2019) [PubMed]  Article 
Target
Name:
Cyclin-Y
Synonyms:
C10orf9 | CBCP1 | CCNY | CCNY_HUMAN | CFP1 | Cyc-Y | Cyclin box protein 1 | Cyclin fold protein 1 | Cyclin-Y | cyclin-X
Type:
PROTEIN
Mol. Mass.:
39339.72
Organism:
Homo sapiens
Description:
ChEMBL_118346
Residue:
341
Sequence:
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
  
Inhibitor
Name:
BDBM50535536
Synonyms:
CHEMBL4544087
Type:
Small organic molecule
Emp. Form.:
C30H33F3N6O10S
Mol. Mass.:
726.677
SMILES:
OC(=O)C(F)(F)F.COc1cc(OC)c(C(=O)Nc2c[nH]nc2C(=O)NC2CCN(CC2)S(=O)(=O)c2cccc(NC(=O)C=C)c2)c(OC)c1
Structure:
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