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Target
Reverse transcriptase
Ligand
BDBM50536229
Substrate
n/a
Meas. Tech.
ChEMBL_1933122 (CHEMBL4478774)
IC50
100±n/a nM
Citation
 Elgaher, WA; Sharma, KK; Haupenthal, J; Saladini, F; Pires, M; Real, E; Mély, Y; Hartmann, RW Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors. J Med Chem 59:7212-22 (2016) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus type 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50536229
Synonyms:
CHEMBL4524634
Type:
Small organic molecule
Emp. Form.:
C19H15Cl2N3O5S2
Mol. Mass.:
500.376
SMILES:
CS(=O)(=O)Nc1ccc(NC(=O)Nc2sc(cc2C(O)=O)-c2ccc(Cl)c(Cl)c2)cc1
Structure:
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