Reaction Details Report a problem with these data
Target
P2X purinoceptor 4
Ligand
BDBM50399207
Substrate
n/a
Meas. Tech.
ChEMBL_1933669 (CHEMBL4479321)
IC50
500±n/a nM
Citation
 Park, JH; Williams, DR; Lee, JH; Lee, SD; Lee, JH; Ko, H; Lee, GE; Kim, S; Lee, JM; Abdelrahman, A; Müller, CE; Jung, DW; Kim, YC Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion. J Med Chem 59:7410-30 (2016) [PubMed]  Article 
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM50399207
Synonyms:
CHEMBL2180179
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2O2
Mol. Mass.:
355.185
SMILES:
Brc1cccc(c1)C1=NCC(=O)Nc2c1oc1ccccc21 |t:8|
Structure:
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