Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM50536653
Substrate
n/a
Meas. Tech.
ChEMBL_1933876 (CHEMBL4479528)
IC50
>10000±n/a nM
Citation
 Temple, KJ; Duvernay, MT; Young, SE; Wen, W; Wu, W; Maeng, JG; Blobaum, AL; Stauffer, SR; Hamm, HE; Lindsley, CW Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against ?-Thrombin. J Med Chem 59:7690-5 (2016) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM50536653
Synonyms:
CHEMBL4593803
Type:
Small organic molecule
Emp. Form.:
C21H14F5N3O2
Mol. Mass.:
435.3468
SMILES:
OCc1c(-c2cncnc2)c2cc(OC(F)(F)F)ccc2n1Cc1ccc(F)cc1F
Structure:
Search PDB for entries with ligand similarity: