Target
Kappa-type opioid receptor
Ligand
BDBM50092513
Substrate
n/a
Meas. Tech.
ChEMBL_145389 (CHEMBL750079)
Ki
1980±n/a nM
Citation
 Siener, TCambareri, AKuhl, UEnglberger, WHaurand, MKögel, BHolzgrabe, U Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones. J Med Chem 43:3746-51 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50092513
Synonyms:
3-((4-Chloro-phenyl)-{[(4-chloro-phenyl)-ethoxycarbonyl-methyl]-methyl-amino}-methyl)-1-methyl-4-oxo-piperidine-3-carboxylic acid ethyl ester | CHEMBL366367
Type:
Small organic molecule
Emp. Form.:
C27H30Cl2N2O5
Mol. Mass.:
533.444
SMILES:
CCOC(=O)C12CN(C)CC(C(N(C)C1c1ccc(Cl)cc1)c1ccc(Cl)cc1)(C(=O)OCC)C2=O |TLB:13:12:34:7.9.6,15:14:34:7.9.6,22:11:34:7.9.6|
Structure:
Search PDB for entries with ligand similarity: