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Target
Kappa-type opioid receptor
Ligand
BDBM50092518
Substrate
n/a
Meas. Tech.
ChEMBL_145390 (CHEMBL750080)
Ki
18±n/a nM
Citation
 Siener, T; Cambareri, A; Kuhl, U; Englberger, W; Haurand, M; Kögel, B; Holzgrabe, U Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones. J Med Chem 43:3746-51 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50092518
Synonyms:
3-[{[Methoxycarbonyl-(4-methoxy-phenyl)-methyl]-methyl-amino}-(4-methoxy-phenyl)-methyl]-1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester | CHEMBL177957
Type:
Small organic molecule
Emp. Form.:
C27H32N2O7
Mol. Mass.:
496.5522
SMILES:
COC(=O)C12CN(C)CC(C(N(C)C1c1ccc(OC)cc1)c1ccc(OC)cc1)(C(=O)OC)C2=O |TLB:12:11:34:6.5.8,22:10:34:6.5.8,14:13:34:6.5.8|
Structure:
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