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Target
ATP-dependent RNA helicase DDX1
Ligand
BDBM50537058
Substrate
n/a
Meas. Tech.
ChEMBL_1935574 (CHEMBL4481333)
IC50
>200000±n/a nM
Citation
 Brai, A; Martelli, F; Riva, V; Garbelli, A; Fazi, R; Zamperini, C; Pollutri, A; Falsitta, L; Ronzini, S; Maccari, L; Maga, G; Giannecchini, S; Botta, M DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection. J Med Chem 62:2333-2347 (2019) [PubMed]  Article 
Target
Name:
ATP-dependent RNA helicase DDX1
Synonyms:
DBP-RB | DDX1 | DDX1_HUMAN | DEAD box protein 1 | DEAD box protein retinoblastoma
Type:
PROTEIN
Mol. Mass.:
82440.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_811952
Residue:
740
Sequence:
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
  
Inhibitor
Name:
BDBM50537058
Synonyms:
CHEMBL4531719
Type:
Small organic molecule
Emp. Form.:
C20H23N5O
Mol. Mass.:
349.4295
SMILES:
CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C)cc1
Structure:
Search PDB for entries with ligand similarity: