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Target
Serine/threonine-protein kinase NLK
Ligand
BDBM50537135
Substrate
n/a
Meas. Tech.
ChEMBL_1935742 (CHEMBL4481501)
Kd
2600±n/a nM
Citation
 Asquith, CRM; Berger, BT; Wan, J; Bennett, JM; Capuzzi, SJ; Crona, DJ; Drewry, DH; East, MP; Elkins, JM; Fedorov, O; Godoi, PH; Hunter, DM; Knapp, S; Müller, S; Torrice, CD; Wells, CI; Earp, HS; Willson, TM; Zuercher, WJ SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem 62:2830-2836 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase NLK
Synonyms:
LAK1 | NLK | NLK_HUMAN | Serine/threonine protein kinase NLK
Type:
PROTEIN
Mol. Mass.:
58306.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774580
Residue:
527
Sequence:
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
  
Inhibitor
Name:
BDBM50537135
Synonyms:
CHEMBL4592501
Type:
Small organic molecule
Emp. Form.:
C19H20N2O4
Mol. Mass.:
340.3731
SMILES:
COc1ccc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2c1
Structure:
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