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Target
Bone morphogenetic protein 1
Ligand
BDBM50093821
Substrate
n/a
Meas. Tech.
ChEBML_158893
IC50
67±n/a nM
Citation
 Dankwardt, SM; Billedeau, RJ; Lawley, LK; Abbot, SC; Martin, RL; Chan, CS; Van Wart, HE; Walker, KA Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase. Bioorg Med Chem Lett 10:2513-6 (2001) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein 1
Synonyms:
BMP-1 | BMP1 | BMP1_HUMAN | Mammalian tolloid protein | PCOLC | PCP | Procollagen C-proteinase | mTld
Type:
PROTEIN
Mol. Mass.:
111254.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_518962
Residue:
986
Sequence:
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
  
Inhibitor
Name:
BDBM50093821
Synonyms:
CHEMBL310772 | {(S)-2-[(2S,3S)-2-(4-Chloro-2,5-dimethyl-benzenesulfonylamino)-3-methyl-pentanoylamino]-2-hydroxycarbamoyl-ethyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C25H33ClN4O7S
Mol. Mass.:
569.07
SMILES:
CC[C@H](C)[C@H](NS(=O)(=O)c1cc(C)c(Cl)cc1C)C(=O)N[C@@H](CNC(=O)OCc1ccccc1)C(=O)NO
Structure:
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