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Target
Arginase-1
Ligand
BDBM50538532
Substrate
n/a
Meas. Tech.
ChEMBL_1973101 (CHEMBL4605919)
IC50
2630±n/a nM
Citation
 Mitcheltree, MJ; Li, D; Achab, A; Beard, A; Chakravarthy, K; Cheng, M; Cho, H; Eangoor, P; Fan, P; Gathiaka, S; Kim, HY; Lesburg, CA; Lyons, TW; Martinot, TA; Miller, JR; McMinn, S; O'Neil, J; Palani, A; Palte, RL; Saurí, J; Sloman, DL; Zhang, H; Cumming, JN; Fischer, C Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. ACS Med Chem Lett 11:582-588 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50538532
Synonyms:
CHEMBL4642576
Type:
Small organic molecule
Emp. Form.:
C12H22BNO4
Mol. Mass.:
255.118
SMILES:
[H][C@]12CCC[C@@]1([H])[C@H](CCCB(O)O)[C@@](N)(C2)C(O)=O |r|
Structure:
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