Reaction Details Report a problem with these data
Target
Papain
Ligand
BDBM50094934
Substrate
n/a
Meas. Tech.
ChEBML_152642
IC50
207±n/a nM
Citation
 Schirmeister, T (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors. Bioorg Med Chem Lett 10:2647-51 (2000) [PubMed]  Article 
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
  
Inhibitor
Name:
BDBM50094934
Synonyms:
CHEMBL329821 | Oxirane-2,3-dicarboxylic acid diethyl ester
Type:
Small organic molecule
Emp. Form.:
C8H12O5
Mol. Mass.:
188.1779
SMILES:
CCOC(=O)C1OC1C(=O)OCC
Structure:
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