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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM99917
Substrate
n/a
Meas. Tech.
ChEMBL_1980073 (CHEMBL4613335)
IC50
67000±n/a nM
Citation
 Wang, Y; He, J; Liao, M; Hu, M; Li, W; Ouyang, H; Wang, X; Ye, T; Zhang, Y; Ouyang, L An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. Eur J Med Chem 161:48-77 (2019) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM99917
Synonyms:
4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide | US8501991, Tenovin 6
Type:
Small organic molecule
Emp. Form.:
C25H34N4O2S
Mol. Mass.:
454.628
SMILES:
CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Structure:
Search PDB for entries with ligand similarity: