Reaction Details Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM160473
Substrate
n/a
Meas. Tech.
ChEMBL_1981487 (CHEMBL4614749)
IC50
>30000±n/a nM
Citation
Mainolfi, N; Ehara, T; Karki, RG; Anderson, K; Mac Sweeney, A; Liao, SM; Argikar, UA; Jendza, K; Zhang, C; Powers, J; Klosowski, DW; Crowley, M; Kawanami, T; Ding, J; April, M; Forster, C; Serrano-Wu, M; Capparelli, M; Ramqaj, R; Solovay, C; Cumin, F; Smith, TM; Ferrara, L; Lee, W; Long, D; Prentiss, M; De Erkenez, A; Yang, L; Liu, F; Sellner, H; Sirockin, F; Valeur, E; Erbel, P; Ostermeier, D; Ramage, P; Gerhartz, B; Schubart, A; Flohr, S; Gradoux, N; Feifel, R; Vogg, B; Wiesmann, C; Maibaum, J; Eder, J; Sedrani, R; Harrison, RA; Mogi, M; Jaffee, BD; Adams, CM Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases J Med Chem 63:5697-5722 (2020) [PubMed] Article
More Info.:
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV