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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50540458
Substrate
n/a
Meas. Tech.
ChEMBL_1981908 (CHEMBL4615170)
Ki
0.524807±n/a nM
Citation
 Del Bello, F; Bonifazi, A; Giorgioni, G; Piergentili, A; Sabbieti, MG; Agas, D; Dell'Aera, M; Matucci, R; Górecki, M; Pescitelli, G; Vistoli, G; Quaglia, W Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus. J Med Chem 63:5763-5782 (2020) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50540458
Synonyms:
CHEMBL4634230
Type:
Small organic molecule
Emp. Form.:
C20H32INO2
Mol. Mass.:
445.3781
SMILES:
[I-].C[N+](C)(C)CC1COCC(O1)(C1CCCCC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: