Reaction Details Report a problem with these data
Target
CAAX prenyl protease 2
Ligand
BDBM50096860
Substrate
n/a
Meas. Tech.
ChEMBL_194934 (CHEMBL879065)
IC50
7000±n/a nM
Citation
 Schlitzer, M; Winter-Vann, A; Casey, PJ Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1. Bioorg Med Chem Lett 11:425-7 (2001) [PubMed]  Article 
Target
Name:
CAAX prenyl protease 2
Synonyms:
CAAX prenyl protease 2 | FACE-2 | FACE2 | FACE2_HUMAN | Farnesylated proteins-converting enzyme 2 | Prenyl protein specific protease | Prenyl protein-specific endoprotease 2 | RCE1 | RCE1 homolog | RCE1A | RCE1B | hRCE1
Type:
PROTEIN
Mol. Mass.:
35839.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_194935
Residue:
329
Sequence:
MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERAGDSEAPLCS
  
Inhibitor
Name:
BDBM50096860
Synonyms:
(E)-3-Biphenyl-4-yl-N-{2-[3-(2,3-dimethyl-phenylsulfamoyl)-phenylcarbamoyl]-ethyl}-acrylamide | CHEMBL423158
Type:
Small organic molecule
Emp. Form.:
C32H31N3O4S
Mol. Mass.:
553.671
SMILES:
Cc1cccc(NS(=O)(=O)c2cccc(NC(=O)CCNC(=O)\C=C\c3ccc(cc3)-c3ccccc3)c2)c1C
Structure:
Search PDB for entries with ligand similarity: