Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50540769
Substrate
n/a
Meas. Tech.
ChEMBL_1982771 (CHEMBL4616033)
Ki
148±n/a nM
Citation
 Amata, E; Dichiara, M; Gentile, D; Marrazzo, A; Turnaturi, R; Arena, E; La Mantia, A; Tomasello, BR; Acquaviva, R; Di Giacomo, C; Rescifina, A; Prezzavento, O Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation. ACS Med Chem Lett 11:889-894 (2020) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50540769
Synonyms:
CHEMBL4647577
Type:
Small organic molecule
Emp. Form.:
C24H31N3O4
Mol. Mass.:
425.5206
SMILES:
[O-][N+](=O)OCc1cccc(c1)C(=O)NCCCCN1CCC(Cc2ccccc2)CC1
Structure:
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