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Target
Endothelin receptor type B
Ligand
BDBM50097182
Substrate
n/a
Meas. Tech.
ChEBML_63862
IC50
470±n/a nM
Citation
 Dasgupta, F; Gangadhar, N; Bruhaspathy, M; Verma, AK; Sarin, S; Mukherjee, AK Peptoids as endothelin receptor antagonists. Bioorg Med Chem Lett 11:555-7 (2001) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_PIG | Endothelin receptor ET-B
Type:
PROTEIN
Mol. Mass.:
49616.89
Organism:
Sus scrofa
Description:
ChEMBL_63872
Residue:
443
Sequence:
MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50097182
Synonyms:
2-[((E)-3-Benzo[1,3]dioxol-5-yl-acryloyl)-(4-methoxy-benzyl)-amino]-3-(1H-indol-3-yl)-propionic acid | CHEMBL356916
Type:
Small organic molecule
Emp. Form.:
C29H26N2O6
Mol. Mass.:
498.5265
SMILES:
COc1ccc(CN(C(Cc2c[nH]c3ccccc23)C(O)=O)C(=O)\C=C\c2ccc3OCOc3c2)cc1
Structure:
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