Target
Aromatase
Ligand
BDBM50097367
Substrate
n/a
Meas. Tech.
ChEMBL_50716 (CHEMBL666795)
IC50
89±n/a nM
Citation
 Recanatini, MBisi, ACavalli, ABelluti, FGobbi, SRampa, AValenti, PPalzer, MPalusczak, AHartmann, RW A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem 44:672-80 (2001) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50097367
Synonyms:
1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one | 4-((1H-imidazol-1-yl)methyl)-1-bromo-9H-xanthen-9-one | CHEMBL421829
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2O2
Mol. Mass.:
355.185
SMILES:
Brc1ccc(Cn2ccnc2)c2oc3ccccc3c(=O)c12
Structure:
Search PDB for entries with ligand similarity: