Reaction Details Report a problem with these data
Target
Tyrosine--tRNA ligase, cytoplasmic
Ligand
BDBM50097747
Substrate
n/a
Meas. Tech.
ChEBML_211024
IC50
190±n/a nM
Citation
Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383. Bioorg Med Chem Lett 11:715-8 (2001) [PubMed] Article
More Info.:
Target
Name:
Tyrosine--tRNA ligase, cytoplasmic
Synonyms:
SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1
Type:
PROTEIN
Mol. Mass.:
59145.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211030
Residue:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
Inhibitor
Name:
BDBM50097747
Synonyms:
CHEMBL162552 | [2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-acetic acid
Type:
Small organic molecule
Emp. Form.:
C17H24N2O9
Mol. Mass.:
400.3805
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)NC([C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)C(O)=O