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Target
Sodium/hydrogen exchanger 2
Ligand
BDBM50058715
Substrate
n/a
Meas. Tech.
ChEBML_141049
IC50
9200±n/a nM
Citation
 Guzman-Perez, A; Wester, RT; Allen, MC; Brown, JA; Buchholz, AR; Cook, ER; Day, WW; Hamanaka, ES; Kennedy, SP; Knight, DR; Kowalczyk, PJ; Marala, RB; Mularski, CJ; Novomisle, WA; Ruggeri, RB; Tracey, WR; Hill, RJ Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett 11:803-7 (2001) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 2
Synonyms:
NHE-2 | NHE2 | Na(+)/H(+) exchanger 2 | SL9A2_HUMAN | SLC9A2 | Solute carrier family 9 member 2
Type:
PROTEIN
Mol. Mass.:
91542.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_397781
Residue:
812
Sequence:
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
  
Inhibitor
Name:
BDBM50058715
Synonyms:
CHEMBL64360 | EMD-96785 | ENIPORIDE | N-(5-Methanesulfonyl-2-methyl-4-pyrrol-1-yl-benzoyl)-guanidine | N-(5-Methanesulfonyl-2-methyl-4-pyrrol-1-yl-benzoyl)-guanidine (Eniporide, EMD-96-875) | N-(diaminomethylene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C14H16N4O3S
Mol. Mass.:
320.367
SMILES:
Cc1cc(c(cc1C(=O)NC(N)=N)S(C)(=O)=O)-n1cccc1
Structure:
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