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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50098545
Substrate
n/a
Meas. Tech.
ChEMBL_3755 (CHEMBL620755)
Ki
36.2±n/a nM
Citation
 Linnanen, T; Brisander, M; Unelius, L; Rosqvist, S; Nordvall, G; Hacksell, U; Johansson, AM Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists. J Med Chem 44:1337-40 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50098545
Synonyms:
(R)-2-(6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-benzene-1,3-diol | CHEMBL281273
Type:
Small organic molecule
Emp. Form.:
C23H21NO2
Mol. Mass.:
343.4183
SMILES:
CN1CCc2cccc-3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c-31 |wD:10.11,(21.88,-10.26,;21.89,-8.74,;23.23,-7.99,;23.23,-6.44,;21.92,-5.67,;21.92,-4.11,;20.57,-3.33,;19.23,-4.1,;19.23,-5.65,;20.57,-6.44,;20.56,-7.98,;19.23,-8.74,;17.88,-7.98,;16.56,-8.74,;15.22,-7.98,;15.22,-6.44,;16.56,-5.67,;16.51,-3.95,;15.13,-3.3,;13.87,-4.17,;15,-1.76,;16.27,-.9,;17.66,-1.55,;17.79,-3.07,;19.31,-2.59,;17.88,-6.44,)|
Structure:
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