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Target
DNA topoisomerase 1
Ligand
BDBM50099251
Substrate
n/a
Meas. Tech.
ChEMBL_208433 (CHEMBL814847)
IC50
5000±n/a nM
Citation
 Kim, DK; Ryu, DH; Lee, JY; Lee, N; Kim, YW; Kim, JS; Chang, K; Im, GJ; Kim, TK; Choi, WS Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues. J Med Chem 44:1594-602 (2001) [PubMed]  Article 
Target
Name:
DNA topoisomerase 1
Synonyms:
DNA topoisomerase I | TOP1_MOUSE | Top-1 | Top1
Type:
PROTEIN
Mol. Mass.:
90922.04
Organism:
Mus musculus
Description:
ChEMBL_208411
Residue:
767
Sequence:
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
  
Inhibitor
Name:
BDBM50099251
Synonyms:
9,16-diethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahydro-1H,12H-[1,4]oxazino[3,2-f]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione | CHEMBL289665
Type:
Small organic molecule
Emp. Form.:
C24H23N3O5
Mol. Mass.:
433.4565
SMILES:
CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc3OCCNc3c12
Structure:
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