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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50099259
Substrate
n/a
Meas. Tech.
ChEMBL_2955 (CHEMBL617895)
Ki
50±n/a nM
Citation
 Rowley, M; Hallett, DJ; Goodacre, S; Moyes, C; Crawforth, J; Sparey, TJ; Patel, S; Marwood, R; Patel, S; Thomas, S; Hitzel, L; O'Connor, D; Szeto, N; Castro, JL; Hutson, PH; MacLeod, AM 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem 44:1603-14 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50099259
Synonyms:
6-Fluoro-3-(4-fluoro-piperidin-3-yl)-2-thiophen-3-yl-1H-indole | CHEMBL44312
Type:
Small organic molecule
Emp. Form.:
C17H16F2N2S
Mol. Mass.:
318.384
SMILES:
F[C@@H]1CCNCC1c1c([nH]c2cc(F)ccc12)-c1ccsc1
Structure:
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