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Target
Cytochrome P450 4B1
Ligand
BDBM50017716
Substrate
n/a
Meas. Tech.
ChEMBL_1989573 (CHEMBL4623308)
IC50
19000±n/a nM
Citation
 Chen, Y; Li, Q; Li, Q; Xing, S; Liu, Y; Liu, Y; Chen, Y; Liu, W; Feng, F; Sun, H p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. J Med Chem 63:10135-10157 (2020) [PubMed]  Article 
Target
Name:
Cytochrome P450 4B1
Synonyms:
1.14.14.1 | CP4B1_HUMAN | CYP4B1 | CYPIVB1 | Cytochrome P450 4B1 | Cytochrome P450-HP
Type:
PROTEIN
Mol. Mass.:
59005.59
Organism:
Homo sapiens
Description:
ChEMBL_119703
Residue:
511
Sequence:
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
  
Inhibitor
Name:
BDBM50017716
Synonyms:
2,2-Diphenyl-pentanoic acid 2-diethylamino-ethyl ester | 2-(diethylamino)ethyl 2,2-diphenylpentanoate | 2-Benzhydryl-pentanoic acid 2-diethylamino-ethyl ester | CHEMBL282567 | PROADIFEN HYDROCHLORIDE
Type:
Small organic molecule
Emp. Form.:
C23H31NO2
Mol. Mass.:
353.4977
SMILES:
CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1
Structure:
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