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Target
Coagulation factor IX
Ligand
BDBM50543913
Substrate
n/a
Meas. Tech.
ChEMBL_1990659 (CHEMBL4624394)
IC50
480±n/a nM
Citation
 Jayne, CL; Andreani, T; Chan, TY; Chelliah, MV; Clasby, MC; Dwyer, M; Eagen, KA; Fried, S; Greenlee, WJ; Guo, Z; Hawes, B; Hruza, A; Ingram, R; Keertikar, KM; Neelamkavil, S; Reichert, P; Xia, Y; Chackalamannil, S Discovery of hydroxy pyrimidine Factor IXa inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM50543913
Synonyms:
CHEMBL4647759
Type:
Small organic molecule
Emp. Form.:
C18H14N6O
Mol. Mass.:
330.3434
SMILES:
NC(=N)c1ccc2[nH]c(nc2c1)-c1ncnc(-c2ccccc2)c1O
Structure:
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