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Target
Protein FosB/Transcription factor JunD
Ligand
BDBM29615
Substrate
n/a
Meas. Tech.
ChEMBL_1991495 (CHEMBL4625230)
IC50
13100±n/a nM
Citation
 Li, Y; Liu, Z; Aglyamova, G; Chen, J; Chen, H; Bhandari, M; White, MA; Rudenko, G; Zhou, J Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ?FosB homodimers and ?FosB/JunD heterodimers. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Protein FosB/Transcription factor JunD
Synonyms:
Protein fosB/Transcription factor jun-D
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1991495
Components:
This complex has 2 components.
Component 1
Name:
Protein FosB
Synonyms:
FOSB | FOSB_HUMAN | G0/G1 switch regulatory protein 3 | G0S3 | Protein fosB
Type:
PROTEIN
Mol. Mass.:
35915.32
Organism:
Homo sapiens
Description:
ChEMBL_119914
Residue:
338
Sequence:
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
  
Component 2
Name:
Transcription factor JunD
Synonyms:
JUND | JUND_HUMAN | Transcription factor jun-D
Type:
PROTEIN
Mol. Mass.:
35175.00
Organism:
Homo sapiens
Description:
ChEMBL_119874
Residue:
347
Sequence:
METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAAALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSSQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPGELAPAAAAPEAPVYANLSSYAGGAGGAGGAATVAFAAEPVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY
  
Inhibitor
Name:
BDBM29615
Synonyms:
6-methoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | MLS000072167 | SMR000009698 | US11584714, Compound 15 | cid_652912
Type:
Small organic molecule
Emp. Form.:
C14H15NO3
Mol. Mass.:
245.2738
SMILES:
COc1cccc2C3C=CCC3C(Nc12)C(O)=O |c:8|
Structure:
Search PDB for entries with ligand similarity: