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Target
P2X purinoceptor 7
Ligand
BDBM50417267
Substrate
n/a
Meas. Tech.
ChEMBL_1993526 (CHEMBL4627421)
IC50
16±n/a nM
Citation
 Homerin, G; Jawhara, S; Dezitter, X; Baudelet, D; Dufrénoy, P; Rigo, B; Millet, R; Furman, C; Ragé, G; Lipka, E; Farce, A; Renault, N; Sendid, B; Charlet, R; Leroy, J; Phanithavong, M; Richeval, C; Wiart, JF; Allorge, D; Adriouch, S; Vouret-Craviari, V; Ghinet, A Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease. J Med Chem 63:2074-2094 (2020) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50417267
Synonyms:
CHEMBL1271768
Type:
Small organic molecule
Emp. Form.:
C13H12ClF3N2O3
Mol. Mass.:
336.694
SMILES:
CN1[C@@H](COC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r|
Structure:
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