Target
Potassium channel subfamily K member 2
Ligand
BDBM50546011
Substrate
n/a
Meas. Tech.
ChEMBL_2013746 (CHEMBL4667324)
EC50
22400±n/a nM
Citation
 Iwaki, YYashiro, KKokubo, MMori, TWieting, JMMcGowan, KMBridges, TMEngers, DWDenton, JSKurata, HLindsley, CW Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett 29:1601-1604 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 2
Synonyms:
KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:
Protein
Mol. Mass.:
47099.16
Organism:
Homo sapiens (Human)
Description:
O95069
Residue:
426
Sequence:
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
  
Inhibitor
Name:
BDBM50546011
Synonyms:
CHEMBL4741659
Type:
Small organic molecule
Emp. Form.:
C19H12F3NO3S2
Mol. Mass.:
423.429
SMILES:
OC(=O)c1cc(sc1NC(=O)c1ccc(SC(F)(F)F)cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: