Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM50104694
Substrate
n/a
Meas. Tech.
ChEMBL_214524 (CHEMBL819516)
IC50
11700±n/a nM
Citation
 Sodeoka, M; Sampe, R; Kojima, S; Baba, Y; Usui, T; Ueda, K; Osada, H Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. J Med Chem 44:3216-22 (2001) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50104694
Synonyms:
(R)-4-hydroxy-5-(hydroxymethyl)-3-palmitoylfuran-2(5H)-one | (R)-5-Ethyl-3-hexadecanoyl-4-methyl-5H-furan-2-oneo | 3-Hexadecanoyl-4-hydroxy-5-hydroxymethyl-5H-furan-2-one | CHEMBL108441 | RK-682
Type:
Small organic molecule
Emp. Form.:
C21H36O5
Mol. Mass.:
368.5075
SMILES:
CCCCCCCCCCCCCCCC(=O)c1c(O)oc(CO)c1O
Structure:
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