Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM203868
Substrate
n/a
Meas. Tech.
ChEMBL_2014999 (CHEMBL4668577)
IC50
5800±n/a nM
Citation
 Cheng, KJ; Hsieh, CM; Nepali, K; Liou, JP Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye. J Med Chem 63:10533-10593 (2020) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM203868
Synonyms:
(S)-N2-benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrrolidine-1,2-dicarboxamide (5)
Type:
Small organic molecule
Emp. Form.:
C28H28N4O2
Mol. Mass.:
452.5475
SMILES:
Cn1cc(NC(=O)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c2ccccc12 |r|
Structure:
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