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Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50547345
Substrate
n/a
Meas. Tech.
ChEMBL_2017729 (CHEMBL4671307)
Kd
>10000±n/a nM
Citation
 Rinotas, V; Papakyriakou, A; Violitzi, F; Papaneophytou, C; Ouzouni, MD; Alexiou, P; Strongilos, A; Couladouros, E; Kontopidis, G; Eliopoulos, E; Douni, E Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-?B Ligand with a Superior Therapeutic Index. J Med Chem 63:12043-12059 (2020) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE
Type:
PROTEIN
Mol. Mass.:
35484.75
Organism:
Homo sapiens
Description:
ChEMBL_106141
Residue:
317
Sequence:
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
  
Inhibitor
Name:
BDBM50547345
Synonyms:
CHEMBL3741761
Type:
Small organic molecule
Emp. Form.:
C32H30F3N3O2
Mol. Mass.:
545.5947
SMILES:
Cc1cc2occ(CN3CCN(Cc4cn(-c5cccc(c5)C(F)(F)F)c5ccccc45)CC3)c(=O)c2cc1C
Structure:
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