Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50106049
Substrate
n/a
Meas. Tech.
ChEBML_49325
IC50
1780±n/a nM
Citation
Su, T; Wu, Y; Doughan, B; Jia, ZJ; Woolfrey, J; Huang, B; Wong, P; Park, G; Sinha, U; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 11:2947-50 (2001) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50106049
Synonyms:
(R)-2-(3-Carbamimidoyl-benzoyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL100067
Type:
Small organic molecule
Emp. Form.:
C30H27N5O5S
Mol. Mass.:
569.631
SMILES:
NC(=N)c1cccc(c1)C(=O)N1Cc2ccc(O)cc2C[C@@H]1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O