Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50106061
Substrate
n/a
Meas. Tech.
ChEBML_49325
IC50
>10000±n/a nM
Citation
 Su, T; Wu, Y; Doughan, B; Jia, ZJ; Woolfrey, J; Huang, B; Wong, P; Park, G; Sinha, U; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 11:2947-50 (2001) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50106061
Synonyms:
(S)-1-(3-Carbamimidoyl-benzoyl)-pyrrolidine-2-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL101437
Type:
Small organic molecule
Emp. Form.:
C25H25N5O4S
Mol. Mass.:
491.562
SMILES:
NC(=N)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Structure:
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