Reaction Details Report a problem with these data
Target
Telomeric repeat-binding factor 2
Ligand
BDBM50546773
Substrate
n/a
Meas. Tech.
ChEMBL_2016709 (CHEMBL4670287)
Ki
330±n/a nM
Citation
 Chen, X; Dong, Y; Guo, T; Yang, CY; Chen, Y; Sun, H N-terminal modified cyclopeptidic mimetics of Apollo Bioorg Med Chem Lett 30:127401 (2020) [PubMed] 
Target
Name:
Telomeric repeat-binding factor 2
Synonyms:
TERF2 | TERF2_HUMAN | TRBF2 | TRF2 | TTAGGG repeat-binding factor 2 | Telomeric DNA-binding protein | Telomeric repeat-binding factor 2
Type:
PROTEIN
Mol. Mass.:
59608.94
Organism:
Homo sapiens
Description:
ChEMBL_118257
Residue:
542
Sequence:
MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN
  
Inhibitor
Name:
BDBM50546773
Synonyms:
CHEMBL4782698
Type:
Small organic molecule
Emp. Form.:
C58H98N12O13
Mol. Mass.:
1171.4713
SMILES:
CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r|
Structure:
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