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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50109118
Substrate
n/a
Meas. Tech.
ChEBML_143683
IC50
176±n/a nM
Citation
 Sit, SY; Huang, Y; Antal-Zimanyi, I; Ward, S; Poindexter, GS Novel dihydropyrazine analogues as NPY antagonists. Bioorg Med Chem Lett 12:337-40 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50109118
Synonyms:
4-(3-{3-[3-(4-Cyclohexyl-piperazin-1-yl)-propyl]-ureido}-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | CHEMBL116864
Type:
Small organic molecule
Emp. Form.:
C31H45N5O5
Mol. Mass.:
567.7195
SMILES:
COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1cccc(NC(=O)NCCCN2CCN(CC2)C2CCCCC2)c1 |c:13,t:10|
Structure:
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