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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50110406
Substrate
n/a
Meas. Tech.
ChEBML_143689
IC50
2800.0±n/a nM
Citation
 Itani, H; Ito, H; Sakata, Y; Hatakeyama, Y; Oohashi, H; Satoh, Y Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 2: substituted benzo[a]cycloheptene derivatives. Bioorg Med Chem Lett 12:757-61 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50110406
Synonyms:
CHEMBL164971 | Naphthalene-1-sulfonic acid (1-{2-[(3-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-ylmethyl)-amino]-ethyl}-piperidin-4-ylmethyl)-amide
Type:
Small organic molecule
Emp. Form.:
C31H41N3O3S
Mol. Mass.:
535.741
SMILES:
COc1ccc2CCCC(CNCCN3CCC(CNS(=O)(=O)c4cccc5ccccc45)CC3)Cc2c1
Structure:
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