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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50110415
Substrate
n/a
Meas. Tech.
ChEBML_143689
IC50
1300±n/a nM
Citation
 Itani, H; Ito, H; Sakata, Y; Hatakeyama, Y; Oohashi, H; Satoh, Y Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 2: substituted benzo[a]cycloheptene derivatives. Bioorg Med Chem Lett 12:757-61 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50110415
Synonyms:
CHEMBL164897 | Naphthalene-1-sulfonic acid (4-{[(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amino]-methyl}-cyclohexylmethyl)-amide
Type:
Small organic molecule
Emp. Form.:
C29H36N2O2S
Mol. Mass.:
476.673
SMILES:
O=S(=O)(NC[C@@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1)c1cccc2ccccc12 |wU:5.4,8.8,(20.02,-8.52,;20.02,-6.98,;20.02,-5.43,;18.69,-6.2,;17.36,-6.99,;16.03,-6.22,;15.25,-4.89,;13.73,-4.87,;12.96,-6.2,;11.63,-5.43,;10.29,-6.2,;8.96,-5.43,;7.61,-6.2,;7.61,-7.75,;6.27,-8.52,;4.93,-7.72,;3.6,-8.52,;2.27,-7.75,;2.27,-6.2,;3.6,-5.43,;4.94,-6.2,;6.27,-5.41,;13.73,-7.54,;15.25,-7.54,;21.37,-6.2,;22.13,-7.54,;23.65,-7.54,;24.42,-6.23,;23.65,-4.9,;24.42,-3.58,;23.65,-2.25,;22.13,-2.27,;21.37,-3.59,;22.13,-4.9,)|
Structure:
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